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PubMed · 1806036

Nitroxyl radicals decrease toxicity of cytostatic agents.

N P Konovalova·R F Diatchkovskaya·L M Volkova·V N Varfolomeev
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Abstract

Nitroxyl radicals of a series of piperidineoxyles and pirrolinoxyles increase the tolerance of experimental animals to the injection of otherwise lethal doses of anti-tumor cytostatic agents. Simultaneous injection of nitroxyl radicals in different doses with 6-mercaptopurine, thiophosphamide, cyclophosphamide and the other cytostatic agents results in decreased toxicity and survival of animals. Nitroxyl radicals normalize the level of the oxidized form of P450 cytochrome that is decreased by the injection of lethal doses of cytostatic agents.

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AnimalsAntineoplastic AgentsCyclophosphamideCytochrome P-450 Enzyme SystemDose-Response Relationship, DrugDrug InteractionsFemaleFree RadicalsMercaptopurineMiceNitrogen OxidesThiotepaJournal Article

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N P Konovalova, R F Diatchkovskaya, L M Volkova, V N Varfolomeev. 1991. Nitroxyl radicals decrease toxicity of cytostatic agents.. https://doi.org/10.1097/00001813-199112000-00010

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