Platelet-derived endothelial cell growth factor.

K Miyazono; K Usuki; C H Heldin

doi:10.1016/0955-2235(91)90007-q

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PubMed · 1811791

Platelet-derived endothelial cell growth factor.

K Miyazono·K Usuki·C H Heldin

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Abstract

Platelet-derived endothelial cell growth factor (PD-ECGF) is a 45 kDa single chain polypeptide, which stimulates the DNA synthesis and chemotaxis of endothelial cells in vitro and angiogenesis in vivo. Purification from human platelets and cDNA cloning from a human placental cDNA library, revealed that PD-ECGF is a novel type of peptide without sequence similarity to hitherto known proteins. PD-ECGF is present in human platelets and placenta, and is produced by certain normal and transformed cultured cells; it lacks a hydrophobic leader sequence and most of the protein remains inside the producer cells. Analysis of PD-ECGF produced by cultured cells, revealed that it contains nucleotide(s) covalently bound to serine residues. The in vivo function of PD-ECGF is not known; its target cell specificity and tissue distribution suggest roles in angiogenesis of the placenta and in the maintenance of the integrity of the endothelial cell layer of blood vessels. PD-ECGF may have a clinical utility in the stimulation of wound healing and re-endothelialization of vessels.

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Amino Acid Sequence Chromosome Mapping Chromosomes, Human, Pair 22 Humans Molecular Sequence Data Thymidine Phosphorylase Wound Healing Comparative Study Journal Article Review

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K Miyazono, K Usuki, C H Heldin. 1991. Platelet-derived endothelial cell growth factor.. https://doi.org/10.1016/0955-2235(91)90007-q

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