Dextrorphan blocks long- but not short-term memory in a passive avoidance task in rats.

J Sierocinska; E Nikolaev; W Danysz; L Kaczmarek

doi:10.1016/0014-2999(91)90780-t

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Dextrorphan blocks long- but not short-term memory in a passive avoidance task in rats.

J Sierocinska·E Nikolaev·W Danysz·L Kaczmarek

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Abstract

In the present study a mixed sigma and PCP (phencyclidine) site ligand, dextrorphan (22 mg/kg), blocked long- but not short-term memory in a passive avoidance task. This effect was not accompanied by any behavioral alterations that could interfere with passive avoidance performance. The action of dextrorphan was shared by a selective NMDA (N-methyl-D-aspartate) receptor antagonist, MK-801 (5-methyl-10,11-dihydro-5H-dibenzocyclohepten-5,10-imine maleate, 0.1 mg/kg). The results suggest that dextrorphan affects long-term memory, probably via blockade of NMDA receptors.

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Animals Avoidance Learning Dextrorphan Male Memory Memory, Short-Term Rats Rats, Inbred Strains Journal Article

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J Sierocinska, E Nikolaev, W Danysz, L Kaczmarek. 1991-11-19. Dextrorphan blocks long- but not short-term memory in a passive avoidance task in rats.. https://doi.org/10.1016/0014-2999(91)90780-t

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