Fibronectin immunoreactivity in neural trauma.

R A Egan; V K Vijayan

doi:10.1016/0006-8993(91)91421-v

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PubMed · 1814578

Fibronectin immunoreactivity in neural trauma.

R A Egan·V K Vijayan

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Abstract

The presence of extracellular matrix protein fibronectin (FN) at the site of neural trauma was examined using immunohistochemical methods. At 2, 4 and 7 days following a penetrating wound through the rat cerebral cortex, FN staining was detected in the neuropil and in non-neuronal cells adjacent to the wound. FN-stained cells were GFAP-negative and were identified as brain macrophages based on cell surface staining for CR3 complement receptor. Our findings suggest a role for FN in the repair of neural trauma.

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Animals Astrocytes Brain Injuries Cerebral Cortex Fibronectins Glial Fibrillary Acidic Protein Hypertrophy Macrophages Neurons Rats Rats, Inbred F344 Time Factors Wounds, Penetrating Journal Article Research Support, U.S. Gov't, P.H.S.

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R A Egan, V K Vijayan. 1991-12-24. Fibronectin immunoreactivity in neural trauma.. https://doi.org/10.1016/0006-8993(91)91421-v

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