Mammalian FMRF-NH2-like peptide in rat pituitary: decrease by osmotic stimulus.

E A Majane; H Y Yang

doi:10.1016/0196-9781(91)90211-7

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Mammalian FMRF-NH2-like peptide in rat pituitary: decrease by osmotic stimulus.

E A Majane·H Y Yang

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Abstract

Previous studies with the Brattleboro rat suggested a possible interaction at the pituitary level between AVP and the neuropeptide, F-8-F-NH2. In order to test this hypothesis, we studied the effect of various osmotic stimuli on neurohypophyseal F-8-F-NH2. In rats drinking 2% NaCl solution for two days, neural lobe AVP and F-8-F-NH2 levels were equally reduced by 87%. After maximal depletion, pituitary levels of F-8-F-NH2 and AVP rebounded in parallel when normal drinking water was reintroduced. Pituitary stalk transection depleted neurohypophyseal F-8-F-NH2. The results of this study suggest that neurohypophyseal F-8-F-NH2 originates from the hypothalamus and, furthermore, is coreleased along with AVP in response to hyperosmotic stimuli.

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Amino Acid Sequence Animals Arginine Vasopressin Chromatography, High Pressure Liquid Kinetics Male Molecular Sequence Data Neuropeptides Oligopeptides Osmotic Pressure Pituitary Gland, Posterior Rats Rats, Inbred Strains Saline Solution, Hypertonic Journal Article

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E A Majane, H Y Yang. Mammalian FMRF-NH2-like peptide in rat pituitary: decrease by osmotic stimulus.. https://doi.org/10.1016/0196-9781(91)90211-7

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