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PubMed · 1818333

Transmembrane signalling by interferon-alpha.

L M Pfeffer·O R Colamonici
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Abstract

Human leukocyte interferon (IFN-alpha) binds to discrete cell surface receptors on target cells, and thereby alters gene expression. Transmembrane signaling by IFN-alpha involves the production of DAG without an increased intracellular free calcium concentration, and the subsequent activation of calcium-independent isoforms of PKC (beta and epsilon). Selective PKC inhibitors (H-7 and staurosporine) can block the ability of IFN-alpha to activate the transcription of a distinct set of genes, called the IFN-stimulated genes (ISG), and to protect cells against viral infection. IFN-alpha also induces the rapid changes in protein phosphorylation, which may include latent transcription factors for ISGs.

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AnimalsHumansInterferon-alphaSignal TransductionJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.Review

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L M Pfeffer, O R Colamonici. 1991. Transmembrane signalling by interferon-alpha.. https://doi.org/10.1016/0163-7258(91)90005-7

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