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PubMed · 1819729

Hypoxia, PAF, and necrotizing enterocolitis.

M S Caplan·X M Sun·W Hsueh
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Abstract

Necrotizing enterocolitis (NEC) is an important neonatal disease with a high mortality rate. The pathophysiology is unclear but epidemiologic studies suggest that hypoxia and infection are important risk factors. In this review we discuss the effect of hypoxia and platelet-activating factor (PAF) on intestinal blood flow and intestinal necrosis, and implicate PAF as an important mediator in hypoxia-induced intestinal injury. Finally we provide evidence that PAF may be important in neonatal NEC.

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AnimalsAzepinesEnterocolitisHumansHypoxiaIntestinesNecrosisPlatelet Activating FactorQuinolinium CompoundsTriazolesJournal ArticleResearch Support, U.S. Gov't, P.H.S.Review

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M S Caplan, X M Sun, W Hsueh. 1991. Hypoxia, PAF, and necrotizing enterocolitis.. https://doi.org/10.1007/bf02536562

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