Perforated synapses and plasticity. A developmental overview.

D G Jones; W Itarat; R K Calverley

doi:10.1007/bf02935547

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Perforated synapses and plasticity. A developmental overview.

D G Jones·W Itarat·R K Calverley

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Abstract

Against a background of existing models relating perforated synapses to synaptic plasticity, the numerical density and frequency of perforated synapses in rat neocortex have been assessed from 1 d to 22 mo of age using the disector procedure, and changes in their morphology were assessed using 3-D computer reconstructions. The data point toward perforated and nonperforated synapses being separate synaptic populations from early in development, and with perforated synapses playing a part in the maintenance of neuronal postsynaptic density surface area from mid-adulthood onwards. This suggests that they play a crucial role in synaptic plasticity, although its nature may be different from that postulated by most recent workers.

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Animals Image Processing, Computer-Assisted Models, Molecular Neuronal Plasticity Parietal Lobe Rats Synapses Journal Article Research Support, Non-U.S. Gov't Review

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D G Jones, W Itarat, R K Calverley. 1991. Perforated synapses and plasticity. A developmental overview.. https://doi.org/10.1007/bf02935547

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