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PubMed · 1824082

Changes of ligand binding after membrane phosphorylation.

R Krulík·P Bures·D Simůnková·M Havránek
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Abstract

Phosphorylation of synaptic plasma brain membranes (SPM) causes a decrease of the specific binding of demethylated tricyclic antidepressants (TCA) and changes the affinity of 3H-imipramine and 3H-desmethylimipramine binding. The decrease of TCA binding was found also in lymphocyte membranes. In platelet membranes a decreased binding was found only with demethylated dibenzazepine derivatives. Bmax and Kd values are also decreased in the presence of phosphatidic acid or alpha-glycerolphosphate.

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AnimalsAntidepressive Agents, TricyclicCattleDealkylationDesipramineDibenzazepinesHumansImipramineIn Vitro TechniquesKineticsLigandsPhosphorylationSynaptic MembranesJournal Article

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R Krulík, P Bures, D Simůnková, M Havránek. 1991. Changes of ligand binding after membrane phosphorylation.. https://doi.org/10.1515/dmdi.1991.9.3-4.293

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