T-cell memory: the connection between function, phenotype and migration pathways.

C R Mackay

doi:10.1016/0167-5699(91)90051-t

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T-cell memory: the connection between function, phenotype and migration pathways.

C R Mackay

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Abstract

Immunological memory is a fundamental feature of vertebrate immune systems, providing enhanced protection against previously encountered antigens. The established view has been that immunological memory results from clonal expansion and long-term survival of specialized memory cells. Recently, the nature of memory T cells has come under closer scrutiny because of the ability to distinguish naive and memory T cells phenotypically, particularly in humans. In this article, Charles Mackay discusses three features of memory T cells that help to explain the nature and function of these cells: the increased expression of adhesion and activation molecules on memory T cells, their potent functional status and their specific pathways of recirculation.

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Animals Antigens, CD Cell Adhesion Molecules Histocompatibility Antigens Humans Immunologic Memory Immunophenotyping Leukocyte Common Antigens Lymphocyte Activation T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Review

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C R Mackay. 1991. T-cell memory: the connection between function, phenotype and migration pathways.. https://doi.org/10.1016/0167-5699(91)90051-t

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