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PubMed · 1840317

Mitogenic response to colony-stimulating factor 1.

C J Sherr
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Abstract

The proliferative effects of colony-stimulating factor 1 (CSF-1) on cells of the mononuclear phagocyte lineage are mediated by the CSF-1 receptor tyrosine kinase, which triggers intracellular signal transduction through multiple second messenger pathways. CSF-1 is required throughout G1 to stimulate both immediate- and delayed-early responses that ensure entry of macrophages into S phase. Because CSF-1 induces the expression of different sets of cellular genes during early and late G1, products of the immediate-early response might modulate the effects of ensuing receptor signals to facilitate G1 progression. Targets of the delayed-early response include novel cyclin genes that may play a role in S phase commitment.

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AnimalsCell CycleCell DifferentiationCell DivisionGrowth SubstancesHematopoietic Stem CellsMacrophage Colony-Stimulating FactorMacrophagesMiceMice, Mutant StrainsModels, BiologicalPhosphorylationProtein Processing, Post-TranslationalProtein-Tyrosine KinasesProto-Oncogene ProteinsReceptor, Macrophage Colony-Stimulating FactorSecond Messenger SystemsTranscription FactorsJournal ArticleReview

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C J Sherr. Mitogenic response to colony-stimulating factor 1.. https://doi.org/10.1016/0168-9525(91)90263-p

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