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PubMed · 184570

[Extrapyramidal and presenile dementia. Relation between symptoms of dementia and cerebral transmitters, particularly dopamine].

V Kristensen
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AcetylcholineBrainDementiaDopamineHumansLevodopaParkinson DiseaseSynaptic TransmissionEnglish AbstractJournal Article

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V Kristensen. 1976-08-16. [Extrapyramidal and presenile dementia. Relation between symptoms of dementia and cerebral transmitters, particularly dopamine].. https://pubmed.ncbi.nlm.nih.gov/184570/

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PubMed1979

Ca2+-dependent protein phosphorylation of purely cholinergic Torpedo synaptosomes.

Preincubation of intact, purely cholinergic Torpedo synaptosomes with [32P]Pi results in the incorporation of 32P into about 10 specific proteins. Depolarizing the Torpedo synaptosomes by a high K+ buffer or treatment with the Ca2+ ionophore A23187 result in Ca2+ uptake, in acetylcholine (ACh) release, and in a marked increase of 32P incorporation into a specific protein band with an apparent subunit molecular weight of 100,000 (band alpha). The kinetics of synaptosomal 45Ca2+ uptake, of 32P incorporation into band alpha, and of ACh release is similar and reach maximal values about 45 s after the synaptosomes have been treated. Sr2+ and Ba2+ can replace Ca2+ in evoking both K+ depolarization-dependent ACh release and 32P incorporation into band alpha. The effectiveness of these ions (Ca2+ greater than Sr2+ greater than Ba2+) is similar in both cases. The data presented suggest that Ca2+ accumulation by Torpedo synaptosomes leads to an increase in the phosphorylation of a specific protein and to ACh release. This phosphoprotein may be involved in the regulation of presynaptic processes which underly ACh release.

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