Interleukin 4 receptor expression on human lung tumors and normal lung.

M F Tungekar; H Turley; M S Dunnill; K C Gatter; M A Ritter; A L Harris

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PubMed · 1846310

Interleukin 4 receptor expression on human lung tumors and normal lung.

M F Tungekar·H Turley·M S Dunnill·K C Gatter·M A Ritter·A L Harris

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Abstract

Interleukin 4 (IL-4) receptors were detected by a monoclonal antibody on tumor cells of 10 of 29 squamous cell carcinomas and 6 of 17 adenocarcinomas of the lung. None of the small cell carcinomas or carcinoid tumors stained. Parallel sections stained for epidermal growth factor receptors showed that all but 2 of the IL-4 receptor-positive tumors also expressed epidermal growth factor receptors. Positive labeling for IL-4 receptors was also obtained on nonneoplastic bronchial epithelium and on lymphocytes and macrophages infiltrating the tumor stroma. The role of IL-4 and its receptor in normal human lung is unknown, but the expression of IL-4 receptors on particular subtypes of lung tumors suggests that they may have a role in differentiation or proliferation of squamous and adenocarcinomas.

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Adenocarcinoma Antibodies, Monoclonal Carcinoid Tumor Carcinoma, Small Cell ErbB Receptors Humans Immunoenzyme Techniques Interleukin-4 Lung Lung Neoplasms Receptors, Interleukin-4 Receptors, Mitogen Journal Article Research Support, Non-U.S. Gov't

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M F Tungekar, H Turley, M S Dunnill, K C Gatter, M A Ritter, A L Harris. 1991-01-01. Interleukin 4 receptor expression on human lung tumors and normal lung.. https://pubmed.ncbi.nlm.nih.gov/1846310/

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