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PubMed · 1848870

Bowenoid papulosis.

R A Schwartz·C K Janniger
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Abstract

Bowenoid papulosis is an uncommon genital dysplasia induced by human papillomavirus infection. Clinically, it usually resembles persistent warts, but histologically it may be suggestive of squamous cell carcinoma in situ. This unusual disorder and recent advances in our understanding of it are reviewed.

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Bowen's DiseaseDiagnosis, DifferentialFemaleGenital Neoplasms, FemaleGenital Neoplasms, MaleHumansMalePapillomaviridaeSkin NeoplasmsTumor Virus InfectionsJournal ArticleReview

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BibTeXRIS

R A Schwartz, C K Janniger. 1991. Bowenoid papulosis.. https://doi.org/10.1016/0190-9622(91)70039-5

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The removal of keratinocyte (KC) nuclear DNA by deoxyribonucleases (DNases) is an important step in the formation of normal stratum corneum (SC). However, the molecular identity of the DNA-degrading enzymes has so far remained elusive. Here we show that the endonuclease DNase1-like 2 (DNase1L2) is preferentially expressed in the epidermis and that its expression correlates with terminal differentiation of KC in vitro and in vivo. In biopsies of normal skin, DNase1L2 mRNA was regularly found in suprabasal KC and DNase1L2 protein was highly abundant in the stratum granulosum. In contrast to normal skin, DNase1L2 expression was downregulated in parakeratotic epidermis such as in psoriatic lesions. When DNase1L2 gene expression was knocked down by small interfering RNA in a human skin equivalent model, nuclei were maintained through all layers of the SC. Taken together, our data demonstrate that DNase1L2 plays an essential role in DNA degradation during terminal differentiation of epidermal KC.

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