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PubMed · 1852605

Curved DNA without AA/TT dinucleotide step.

I Brukner·V Jurukovski·M Konstantinović·A Savić
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Abstract

The evidence is accumulating that dinucleotide steps other than AA/TT affect DNA flexure of AnTm (m + n greater than = 4) containing fragments. However, it is not clear whether macroscopic DNA flexure without AA/TT steps might occur. In this paper we demonstrate the anomaly in electrophoretic mobility of non AA/TT repetitive DNA sequences which is a function of sequence phasing. Therefore, our results show that PyPu (TA) and AG/CT steps, angulary separated by close to 180 degrees from Pu/Py (GC) and GG/CC steps, bend DNA, even in the absence of AnTm tracts.

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Adenine NucleotidesBase SequenceDNAElectrophoresis, Polyacrylamide GelMolecular Sequence DataNucleic Acid ConformationNucleotidesOligodeoxyribonucleotidesRepetitive Sequences, Nucleic AcidThymine NucleotidesJournal ArticleResearch Support, Non-U.S. Gov't

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I Brukner, V Jurukovski, M Konstantinović, A Savić. 1991-07-11. Curved DNA without AA/TT dinucleotide step.. https://doi.org/10.1093/nar%2F19.13.3549

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