Selective dopamine antagonists reduce nicotine self-administration.

W A Corrigall; K M Coen

doi:10.1007/bf02244174

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PubMed · 1876661

Selective dopamine antagonists reduce nicotine self-administration.

W A Corrigall·K M Coen

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Abstract

The effects of selective D1 (SCH23390) and D2 (spiperone) dopamine antagonists, as well as of haloperidol, were examined on nicotine self-administration, food-maintained responding, and locomotor activity in rats. Antagonists reduced both operant responding and locomotor activity. Response patterns indicated that motor impairment was not the cause of the decreases, since responding was attenuated only in the latter half of operant sessions. Locomotor activity scores were significantly reduced by SCH23390, but not by spiperone. The effects of dopamine antagonists on nicotine self-administration are different from the effects of these antagonists on cocaine self-administration. Results are discussed in terms of the role of dopamine in drug reinforcement versus its role in sensorimotor integration.

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Animals Benzazepines Conditioning, Operant Dopamine Antagonists Food Haloperidol Male Motor Activity Nicotine Rats Reinforcement Schedule Self Administration Spiperone Journal Article

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W A Corrigall, K M Coen. 1991. Selective dopamine antagonists reduce nicotine self-administration.. https://doi.org/10.1007/bf02244174

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