PubMed · 1882340
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1991-05-15. [Nurses go along].. https://pubmed.ncbi.nlm.nih.gov/1882340/
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BACKGROUNDIncreasing incidence rates of invasive Streptococcus dysgalactiae subspecies equisimilis (iSDSE) have been detected worldwide.AIMWe aimed to investigate iSDSE infection incidence rates in Denmark during 2014-2024, and characterise the genomic population structure of a subset of iSDSE isolates and their antimicrobial resistance (AMR).METHODSUsing national register data, we estimated overall and sex-/age-stratified iSDSE incidences during 2014-2024, by retrospectively identifying cases of invasive infections with group C and G streptococci or S. dysgalactiae (including specified as subspecies equisimilis). From the voluntary national beta-haemolytic streptococci laboratory surveillance system, whole-genome-sequenced isolates from August 2020-September 2022 were used to investigate the iSDSE genomic population structure. Susceptibility to penicillin, erythromycin and clindamycin was determined and AMR genes identified.RESULTSDuring 2014-2024, iSDSE incidence rates increased significantly (linear trend analysis p < 0.001) with mean annual incidence ranging between 10.3 and 16.4 per 100,000, peaking in 2023. Incidence was higher in males, increasing with older age. Nearly 75% of the 1,223 iSDSE isolates belonged to four of 14 genetic clusters. Sequence types (STs) ST20 and ST17 were most prevalent, while emm-type stG62647, a variant associated internationally with higher virulence, dominated. All isolates were phenotypically susceptible to penicillin but approximately 10% were respectively erythromycin and clindamycin resistant. High erythromycin resistance prevalence (57%; 39/68), coinciding with gene ermA, occurred in one genetic cluster.CONCLUSIONThe findings illustrate the need for national registry-based surveillance to detect epidemiological changes and potential outbreaks. Further, continuous genomic surveillance can monitor the occurrence and expansion of genetic clades and AMR genes.
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The aim of the study was to evaluate the effect of an assessment of complications in early pregnancy in an "early pregnancy unit" opened in May 1993. The purpose of the "early pregnancy unit" was to avoid routine admission of women with pain/bleeding in early pregnancy. All general practitioners were informed of the possibility of referring patients to examination and ultrasonography in the "early pregnancy unit" during daytime, instead of acute admission to the ward. Data was compiled from the hospital admission and the emergency unit register for the years 1992-1996. These showed that admissions for early pregnancy complications decreased from 714 (1992) to 315 (1996) accounting for 41% (1992) and 16% (1996) of total admissions to the department, and 23% (1992) and 10% (1996) of the numbers of deliveries, respectively. Women referred between 00:00 hours and 7 a.m. accounted for 23% (1992) and 9% of admissions of total admissions or of deliveries (1996). It is concluded that initiation of the early pregnancy assessment unit resulted in a reduction in the number of admissions. The hospital staff experienced a reduced workload during the night.