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PubMed · 1890742

[B-CLL and bcl-2 gene].

M Adachi·K Imai·A Yachi·Y Tsujimoto
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Abstract

Most of human follicular lymphomas (approximately 90% in U.S.A. or approximately 30% in Japan) possess the t(14; 18) chromosome translocation that directly involves the IgH locus on chromosome 14 and the bcl-2 gene on chromosome 18. The t(14; 18) chromosome translocation occurs nearly exclusively at two hot spots, a major breakpoint clustering region (mbr) within the 2nd exon noncoding region and the minor breakpoint clustering region (mcr) within the 3' flanking region of the bcl-2 gene. Here we show that the rearrangement of the bcl-2 gene occurs in a significant fraction (approximately 10%) of B-CLL. All of the rearranged bcl-2 genes were juxtaposed with Ig lambda or Ig kappa genes, implying that the bcl-2 gene is preferentially linked to the IgL genes in CLL.

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Base SequenceGene RearrangementHumansLeukemia, Lymphocytic, Chronic, B-CellMolecular Sequence DataProto-Oncogene ProteinsProto-Oncogene Proteins c-bcl-2Proto-OncogenesEnglish AbstractJournal Article

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M Adachi, K Imai, A Yachi, Y Tsujimoto. 1991. [B-CLL and bcl-2 gene].. https://pubmed.ncbi.nlm.nih.gov/1890742/

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