2,4-Dichlorophenoxyacetic acid effects on polyamine biosynthesis.

V Rivarola; H Balegno

doi:10.1016/0300-483x(91)90014-r

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2,4-Dichlorophenoxyacetic acid effects on polyamine biosynthesis.

V Rivarola·H Balegno

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Abstract

2,4-Dichlorophenoxyacetic acid (2,4-D) is a herbicide extensively used in agriculture. It was considered of interest to study its toxicity on animal cells. We had previously determined that 1 mM 2,4-D can inhibit cell growth, DNA and protein synthesis of cultured Chinese hamster ovary cells (CHO) with cell accumulation in the G1/S interphase of the cell cycle. The present work examined the effects of 2,4-D on polyamine biosynthesis. The results suggest some possible mechanism of the herbicide's toxic effects on animal cells.

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2,4-Dichlorophenoxyacetic Acid Animals Cell Division Cell Line Culture Media DNA Ornithine Decarboxylase Polyamines Protein Biosynthesis Proteins Putrescine Spermidine Spermidine Synthase Spermine Spermine Synthase Journal Article

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V Rivarola, H Balegno. 1991. 2,4-Dichlorophenoxyacetic acid effects on polyamine biosynthesis.. https://doi.org/10.1016/0300-483x(91)90014-r

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PubMed2007

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2,4-Dichlorophenoxyacetic Acid↗

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