Immunopathogenesis of multiple sclerosis.

H Wekerle

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PubMed · 1891986

Immunopathogenesis of multiple sclerosis.

H Wekerle

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Abstract

The immunopathogenesis of MS is discussed in the light of data recently obtained in Experimental Autoimmune Encephalomyelitis (EAE), a myelin specific experimental autoimmune disease reflecting the first, inflammatory phase of MS plaque generation. EAE is caused by CD4+ T cells specific for defined myelin protein, like MBP and PLP. In rats and mice there is a marked dominance of the autoantigenic peptide epitopes on the one hand, and the T cell receptor V regions on the other. During T cell mediated EAE, clonotypically counterregulatory CD8+ T cells are induced, which specifically neutralize the encephalitogenic T clones.

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Animals Humans Multiple Sclerosis Journal Article Research Support, Non-U.S. Gov't Review

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H Wekerle. 1991. Immunopathogenesis of multiple sclerosis.. https://pubmed.ncbi.nlm.nih.gov/1891986/

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