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Genetic mapping by single sperm typing.

N Arnheim·H Li·X Cui
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Abstract

The polymerase chain reaction makes it possible to analyse DNA sequences in a single cell and has led to a new approach for constructing genetic maps. We describe a procedure called 'sperm typing' which can accurately classify individual meiotic products as recombinant of non-recombinant. This permits the linkage relationships among DNA polymorphisms to be determined without pedigree analysis.

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Chromosome MappingGlobinsHumansMaleParathyroid HormonePolymerase Chain ReactionRecombination, GeneticSpermatozoaJournal ArticleReview

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N Arnheim, H Li, X Cui. 1991. Genetic mapping by single sperm typing.. https://doi.org/10.1111/j.1365-2052.1991.tb00652.x

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