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Two types of linkage between codon usage and gene-expression levels.

T Nakamura·A Suyama·A Wada
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Abstract

The relation between codon usage and gene-expression levels is an intensively investigated and discussed topic in the field of molecular evolution. We statistically analyzed 25 Escherichia coli gene sequences by a new classification of synonymous codons and found that (i) there are two distinct types of linkage between codon usage and gene-expression levels in E. coli, and (ii) one of the two kinds of codon preferences (the codon preference concerned with interaction of GC/AT choice at three codon positions) is observed significantly in weakly expressed genes.

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Base SequenceCodonEscherichia coliGene ExpressionGenes, BacterialMolecular Sequence DataJournal ArticleResearch Support, Non-U.S. Gov't

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T Nakamura, A Suyama, A Wada. 1991-09-02. Two types of linkage between codon usage and gene-expression levels.. https://doi.org/10.1016/0014-5793(91)80923-q

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