B-cell selection and tolerance.

G J Nossal

doi:10.1016/0952-7915(91)90049-7

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B-cell selection and tolerance.

G J Nossal

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Abstract

The B-lymphocyte repertoire can be divided into a primary repertoire of virgin B cells and a secondary repertoire of antigenically experienced cells. Self-tolerance requires that neither of these repertoires contains potentially active cells capable of high-affinity, anti-self antibody production. Recent work has proven that both the primary and the secondary repertoire can be functionally purged, and this mechanism may involve failure of appearance of anti-self clonotypes (clonal abortion) or defects in activation (clonal anergy).

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Animals Animals, Genetically Modified B-Lymphocytes Immune Tolerance Immunoglobulin Heavy Chains Immunoglobulin kappa-Chains Models, Biological Muramidase Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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G J Nossal. 1991. B-cell selection and tolerance.. https://doi.org/10.1016/0952-7915(91)90049-7

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