Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases.

M Arthur; C Molinas; S Dutka-Malen; P Courvalin

doi:10.1016/0378-1119(91)90405-z

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PubMed · 1908809

Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases.

M Arthur·C Molinas·S Dutka-Malen·P Courvalin

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Abstract

Sequencing upstream from the vanA gene of enterococcal plasmid pIP816 that confers Vm resistance revealed the presence of an ORF which could code for a protein of 322 aa designated VanH. Extensive aa similarity was detected between VanH and 2-hydroxycarboxylic acid dehydrogenase. We discuss possible roles for VanH in the synthesis of a novel type of peptidoglycan precursors with lower affinity for Vm.

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Alcohol Oxidoreductases Amino Acid Sequence Bacterial Proteins Base Sequence Carboxylic Acids Drug Resistance, Microbial Enterococcus faecalis Molecular Sequence Data Open Reading Frames Peptidoglycan Plasmids Sequence Alignment Vancomycin Journal Article

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M Arthur, C Molinas, S Dutka-Malen, P Courvalin. 1991-07-15. Structural relationship between the vancomycin resistance protein VanH and 2-hydroxycarboxylic acid dehydrogenases.. https://doi.org/10.1016/0378-1119(91)90405-z

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