T-cell-mediated cytotoxicity.

G Berke

doi:10.1016/0952-7915(91)90031-u

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PubMed · 1910610

T-cell-mediated cytotoxicity.

G Berke

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Abstract

There are two competing theories to explain the mechanism(s) by which cytolytic T lymphocytes kill target cells: granule exocytosis of a pore-forming protein, and contact-induced internal disintegration. Accumulated evidence supports alternative pathways in lymphocytoxicity, possibly reflecting distinct effector functions expressed by different killer cells and cells at different stages of activation.

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Animals Cytotoxicity, Immunologic Humans Membrane Glycoproteins Membrane Proteins Models, Biological Perforin Pore Forming Cytotoxic Proteins Serine Endopeptidases T-Lymphocytes, Cytotoxic Journal Article Review

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G Berke. 1991. T-cell-mediated cytotoxicity.. https://doi.org/10.1016/0952-7915(91)90031-u

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