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PubMed · 1910767

5-Hydroxytryptamine induces electrogenic secretion and simultaneously activates a modulating inhibitory neural circuit in rat small intestine in vitro.

A Beesley·R J Levin
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Abstract

5-Hydroxytryptamine (5-HT) induces electrogenic secretion across rat jejunum and ileum in vitro expressed as an increase in the short-circuit current. Enhancement of this secretory response by previous serosal addition of atropine (1 microM), hexamethonium (0.2 microM) or yohimbine (0.2 microM), especially in the ileum, indicated that 5-HT simultaneously activates an anti-secretory, inhibitory, enteric, neural, cholinergic-adrenergic pathway (ENCAP). A similar inhibitory ENCAP activated by 5-HT has previously been characterized in rat colon in vitro.

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AnimalsAutonomic AgentsElectric ConductivityIn Vitro TechniquesIntestinal SecretionsIntestine, SmallMaleNeural ConductionRatsSerotoninJournal Article

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A Beesley, R J Levin. 1991. 5-Hydroxytryptamine induces electrogenic secretion and simultaneously activates a modulating inhibitory neural circuit in rat small intestine in vitro.. https://doi.org/10.1113/expphysiol.1991.sp003528

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