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Estimating the postantibiotic effect: a two-phase mathematical model.

M N Brunden·B H Yagi·M S Lajiness·G E Zurenko
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Abstract

The postantibiotic effect (PAE) is a suppression of bacterial growth that persists after a short exposure to antimicrobials. The active antibiotic delays the resumption of normal growth. This suppression of bacterial growth following antibiotic removal is described by a two-phase model. The quantification of PAE is a function of the model parameters, for which consistent and asymptotically normal estimators are available.

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M N Brunden, B H Yagi, M S Lajiness, G E Zurenko. 1991. Estimating the postantibiotic effect: a two-phase mathematical model.. https://doi.org/10.1007/bf01061666

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