PubMed · 1927231
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P Foëx. 1991. Right ventricular function during ARDS.. https://doi.org/10.1111/j.1399-6576.1991.tb03402.x
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Traditionally, myocardial ischemia has been viewed as an imbalance in the supply and demand of myocardial oxygen. Stable angina is usually considered to involve a fixed lesion, whereas unstable angina involves a fixed lesion as well as such components as platelet aggregation, thrombotic processes, and vasospasm. Variant angina involves primarily vasospasm. A newer concept holds that most angina results from mixed mechanisms in which both fixed lesions and vasomotor alterations play a role. These mechanisms are responsible for mixed ischemic events, characterized by episodes at varying levels of exertion, with or without anginal pain. This concept would seem to be supported by the occurrence of silent ischemia in the setting of stable, unstable, or variant angina, despite differing pathophysiologic conditions. Ischemic events have important prognostic significance; unfortunately, many are unrecognized by patients. The question whether the treatment of ischemic events will improve prognosis remains a matter of debate.
Prolonged exposure to organic nitrates has been shown to lead to the rapid development of tolerance to the peripheral and coronary vasodilatory effects of these drugs. As a result of this phenomenon, the hemodynamic and anti-ischemic effects of nitrates may be rapidly attenuated in patients with ischemic heart disease, congestive heart failure, or both. This nitrate tolerance appears to be both dose- and time-dependent. Likely mechanisms proposed for its development are multifactorial and include depletion of sulfhydryl groups, a nitrate-mediated increase in blood volume, and neurohormonal stimulation with activation of vasoconstrictive mechanisms.
Intracoronary ultrasonography can provide morphologic and physiologic information on coronary vasomotor responses to pharmacotherapy. Preliminary studies indicate a high correlation between dimensions determined by 2-dimensional echocardiography, angiography, and pathology. Similarly, the emerging data on intracoronary Doppler flow velocity responses beyond atherosclerotic obstructions before, during, and after coronary balloon occlusion will provide further insights into myocardial oxygen supply and its responses to pharmacotherapy during controlled myocardial ischemia.