Thyroid dysfunction associated with immunotherapy for patients with cancer.

D J Schwartzentruber; D E White; M H Zweig; B D Weintraub; S A Rosenberg

doi:10.1002/1097-0142(19911201)68:11<2384::aid-cncr2820681109>3.0.co;2-a

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PubMed · 1933775

Thyroid dysfunction associated with immunotherapy for patients with cancer.

D J Schwartzentruber·D E White·M H Zweig·B D Weintraub·S A Rosenberg

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Abstract

The authors performed a prospective study to evaluate thyroid dysfunction in 130 patients with cancer who were receiving interleukin-2 (IL-2)-based immunotherapy. Primary hypothyroidism was the most common abnormality, occurring in 12% of patients before, 38% during, and 23% after immunotherapy. Hyperthyroidism occurred in 1%, 4%, and 7% of patients at those time intervals. Among patients initially euthyroid (n = 111), primary hypothyroidism developed in 32% during and 14% after immunotherapy, persisting a median of 54 days. Three patients required levothyroxine. Hyperthyroidism developed in 2% of patients during immunotherapy and 6% after. Thyroid dysfunction was not a function of sex, diagnosis, type of treatment, or response to immunotherapy. Elevated titers of antithyroglobulin and antithyroid microsomal antibodies were detected after treatment in 9% and 7%, respectively, of all patients without prior antibody abnormalities and did not correlate with response to therapy. The high incidence of therapy-induced thyroid dysfunction suggests that thyroid function should be carefully monitored in all patients receiving IL-2-based immunotherapy.

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Adolescent Adult Aged Autoantibodies Child Female Humans Hypothyroidism Immunotherapy Interleukin-2 Male Middle Aged Neoplasms Prospective Studies Thyroid Diseases Journal Article

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D J Schwartzentruber, D E White, M H Zweig, B D Weintraub, S A Rosenberg. 1991-12-01. Thyroid dysfunction associated with immunotherapy for patients with cancer.. https://doi.org/10.1002/1097-0142(19911201)68%3A11%3C2384%3A%3Aaid-cncr2820681109%3E3.0.co%3B2-a

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