Chromatin phospholipid changes during rat liver development.

E Albi; M V Magni; R Lazzarini; P B Gahan

doi:10.1002/cbf.290090209

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Chromatin phospholipid changes during rat liver development.

E Albi·M V Magni·R Lazzarini·P B Gahan

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Abstract

The chromatin extracted from rat hepatocytes of different ages has been shown to contain a phospholipid fraction representing 0.47-0.59 per cent of total chromatin in newborn animals and 0.22 per cent in 45-day-old animals. No such age-related differences are observed in the nuclei. The phospholipid composition of the nuclei at different ages shows a higher level of sphingomyelin and a lower level of phosphatidylserine in newborn than in adult animals. Chromatin phospholipids have a completely different composition from that of nuclei with respect to age, particularly in newborn rats, where there is a decrease in phosphatidylcholine and an increase in phosphatidylserine.

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Aging Animals Cell Nucleus Chromatin Female Liver Male Phospholipids Rats Rats, Inbred Strains Journal Article Research Support, Non-U.S. Gov't

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E Albi, M V Magni, R Lazzarini, P B Gahan. 1991. Chromatin phospholipid changes during rat liver development.. https://doi.org/10.1002/cbf.290090209

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