Early postnatal hyperthyroidism improves both working and reference memory in a spatial radial-maze task in adult mice.

W E Crusio; H Schwegler

doi:10.1016/0031-9384(91)90530-2

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Early postnatal hyperthyroidism improves both working and reference memory in a spatial radial-maze task in adult mice.

W E Crusio·H Schwegler

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Abstract

Newborn male pups of the inbred mouse strain DBA/2J were injected with a buffered solution of L-thyroxine, known to induce a hyperplasia of the intra- and infrapyramidal mossy fiber terminal fields (iip-MF). Because previous studies have shown that the size of the iip-MF correlates positively with both reference memory and working memory in a spatial radial maze task, we expected improved performance on such a task in the treated animals. Such an improvement was in fact found for both reference and working memory. We conclude that the iip-MF are functionally involved in the regulation of spatial learning and memory in mice.

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Animals Animals, Newborn Brain Mapping Discrimination Learning Hippocampus Male Mental Recall Mice Mice, Inbred DBA Orientation Retention, Psychology Thyroid Hormones Thyroxine Journal Article

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W E Crusio, H Schwegler. 1991. Early postnatal hyperthyroidism improves both working and reference memory in a spatial radial-maze task in adult mice.. https://doi.org/10.1016/0031-9384(91)90530-2

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