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PubMed · 1955842

Chloroquine distribution in postmortem cases.

J J Kuhlman·R W Mayes·B Levine·R Jones·G N Wagner·M L Smith
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Abstract

Chloroquine concentrations in blood and tissues were examined in overdose and non-overdose cases to determine appropriate ranges for interpretation. Twenty-nine literature overdose cases and 8 non-overdose literature cases were compared with this laboratory's findings. The results indicate significant postmortem redistribution of chloroquine. Combining this laboratory's results and the literature results indicates that using a liver concentration of 150 mg/kg as a cutoff between overdose and non-overdose concentrations properly identified 30 of the 34 published cases containing liver chloroquine and 19 of the 20 presented cases.

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Accidents, AviationBrainChloroquineChromatography, GasDrug OverdoseHumansLiverMilitary PersonnelMultiple TraumaPostmortem ChangesTissue DistributionUnited StatesJournal Article

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J J Kuhlman, R W Mayes, B Levine, R Jones, G N Wagner, M L Smith. 1991. Chloroquine distribution in postmortem cases.. https://pubmed.ncbi.nlm.nih.gov/1955842/

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