Antigenic variation in Borrelia.

I Saint Girons; A G Barbour

doi:10.1016/0923-2508(91)90085-o

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Antigenic variation in Borrelia.

I Saint Girons·A G Barbour

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Abstract

Antigenic variation was demonstrated for the agent of relapsing fever, Borrelia hermsii. The phenomenon is correlated with changes in major surface proteins called Vmp. The genes encoding these antigens are located on linear plasmids. Expression occurs by transposition of genes encoding Vmp to a telomeric expression site located on another linear plasmid. Activation of a vmp gene occurs by placing it downstream from a promoter. Resemblance to the antigenic variation of trypanosomes is discussed.

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Animals Antigenic Variation Blotting, Southern Borrelia Borrelia Infections Humans In Vitro Techniques Membrane Proteins Plasmids Trypanosoma Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.Review

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I Saint Girons, A G Barbour. Antigenic variation in Borrelia.. https://doi.org/10.1016/0923-2508(91)90085-o

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