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An NMR compatible model for solid tumour.

J Reglinski·M al-Kabban·W E Smith·I D Watson·M J Stewart
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Abstract

An NMR model for the study of drug interactions with solid tumour is described. It is based on the use of packed cells in a simple medium. The system is capable of dealing with cellular biochemistry at a molecular level through experiments conducted in a homogeneous field by 1H spin-echo NMR spectroscopy. However, through a simple imaging technique, it is also possible to introduce a spatial element into the chemistry of the packed cells. The use of these complementary NMR methods are illustrated by the action of the cytotoxic agent doxorubicin on cellular glycolysis. A pattern of signals observed in a homogeneous field experiment following oxidative stress are duplicated in the imaging experiment to illustrate the toxins' ability to penetrate the model tumour.

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Antineoplastic AgentsCarcinoma, Small CellHumansLung NeoplasmsMagnetic Resonance ImagingMagnetic Resonance SpectroscopyModels, BiologicalNeoplasmsTumor Cells, CulturedJournal ArticleResearch Support, Non-U.S. Gov't

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J Reglinski, M al-Kabban, W E Smith, I D Watson, M J Stewart. 1990. An NMR compatible model for solid tumour.. https://doi.org/10.1016/0731-7085(90)80110-b

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