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PubMed · 1969070

Shear-induced platelet aggregation.

J R O'Brien
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Abstract

Two platelet mechanisms contribute to haemostasis and thrombosis. (1) Compounds such as thrombin activate glycoprotein IIb/IIIa; fibrinogen is the ligand. The cyclooxygenase pathway is involved and so this process is aspirin sensitive. (2) Shearing forces alone activate a different domain on glycoprotein IIb/IIIa; von Willebrand's factor is the ligand. This process is probably non-enzymatic and is aspirin insensitive. The prevention of shear-induced platelet activation may prove to be more rewarding therapeutically than inhibition of aspirin sensitive pathways.

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Blood CirculationBlood Coagulation TestsBlood ViscosityFibrinogenHemofiltrationHumansIntegrin alpha2Membrane GlycoproteinsPlatelet ActivationPlatelet AggregationThrombastheniavon Willebrand Diseasesvon Willebrand FactorJournal ArticleReview

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J R O'Brien. 1990-03-24. Shear-induced platelet aggregation.. https://doi.org/10.1016/0140-6736(90)90815-m

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