Do CD2 and CD3-TCR T-cell activation pathways function independently?

D Kabelitz

doi:10.1016/0167-5699(90)90016-3

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Do CD2 and CD3-TCR T-cell activation pathways function independently?

D Kabelitz

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Abstract

T cells can be activated either through the CD3-T-cell receptor (TCR) complex or through CD2 (the sheep erythrocyte receptor) via an 'alternate' pathway. A number of studies have suggested that these pathways are linked. Here, Dieter Kabelitz discusses recent advances in understanding the mechanism of T-cell activation, focusing on findings that indicate that certain T cells do not express CD2. The identification of CD2-negative T cells opens a new approach for studying the interrelationship between CD3-TCR and CD2 T-cell activation pathways.

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Animals Antigens, Differentiation, T-Lymphocyte CD2 Antigens CD3 Complex Humans Lymphocyte Activation Receptors, Antigen, T-Cell Receptors, Immunologic T-Lymphocytes Journal Article Research Support, Non-U.S. Gov't Review

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D Kabelitz. 1990. Do CD2 and CD3-TCR T-cell activation pathways function independently?. https://doi.org/10.1016/0167-5699(90)90016-3

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