On remaining cytoplasmic.

A P Pugsley

doi:10.1016/0300-9084(90)90133-2

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On remaining cytoplasmic.

A P Pugsley

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Abstract

The published literature contains a number of examples of normally non-cytoplasmic proteins whose transport out of the cytoplasm is not completely abolished by drastic alterations to their routing signals (signal sequences, etc). Furthermore, there are numerous examples of cytoplasmic proteins that can be routed to and across plasma or organelle membranes by fusing them to routing signals. These 2 sets of observations lead to a re-evaluation of the reliability and accuracy of protein routing and to consideration of the consequences of the errors which might occur.

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Biological Transport Chaperonins Cytoplasm Intracellular Membranes Organelles Protein Processing, Post-Translational Protein Sorting Signals Proteins Receptors, Cell Surface Receptors, Cytoplasmic and Nuclear Receptors, Peptide Journal Article Research Support, Non-U.S. Gov't Review

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A P Pugsley. On remaining cytoplasmic.. https://doi.org/10.1016/0300-9084(90)90133-2

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