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PubMed · 1979049

DNA sequence polymorphisms in Alu repeats.

M Orita·T Sekiya·K Hayashi
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Abstract

We have developed an efficient method for detection of sequence differences in genomic DNA based on a new principle (M. Orita et al., 1989, Genomics 5: 874-879). Using this method, we show here that approximately half the Alu repeats interspersed in the human genome are significantly polymorphic. Analysis of Alu repeat polymorphism should be useful in construction of a high-resolution map and also in identifying genotypes of individuals for clinical and other purposes because the repeats are ubiquitous and the technique for their detection is simple.

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Base SequenceChromosome MappingDNA Mutational AnalysisHumansMolecular Sequence DataPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthRepetitive Sequences, Nucleic AcidComparative StudyJournal ArticleResearch Support, Non-U.S. Gov't

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M Orita, T Sekiya, K Hayashi. 1990. DNA sequence polymorphisms in Alu repeats.. https://doi.org/10.1016/0888-7543(90)90282-y

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