Circling behavior exhibited by a transgenic insertional mutant.

A K Ratty; L W Fitzgerald; M Titeler; S D Glick; J J Mullins; K W Gross

doi:10.1016/0169-328x(90)90050-n

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PubMed · 1980140

Circling behavior exhibited by a transgenic insertional mutant.

A K Ratty·L W Fitzgerald·M Titeler·S D Glick·J J Mullins·K W Gross

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Abstract

We report here of an abnormal circling behavior expressed in the TgX15 transgenic mouse line as a result of insertional mutagenesis. Homozygous transgenic mice expressed the phenotype while heterozygous transgenics were normal. We also found that the dopamine D2 receptor binding sites in the striata of the circling mice were significantly elevated by about 31% compared to normal heterozygous transgenic mice. Other transgenic lines constructed with the same transgene appeared normal suggesting that, in the TgX15 line, a genetic locus significant in mammalian motor behavior has been disrupted.

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Animals Behavior, Animal Mice Mice, Transgenic Mutagenesis, Insertional Neurotransmitter Agents Phenotype Receptors, Dopamine Receptors, Dopamine D2 Rotation Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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A K Ratty, L W Fitzgerald, M Titeler, S D Glick, J J Mullins, K W Gross. 1990. Circling behavior exhibited by a transgenic insertional mutant.. https://doi.org/10.1016/0169-328x(90)90050-n

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