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Overview. Purinergic mechanisms.

G Burnstock
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Abstract

An overview of the history of studies of the biological actions of extracellular ATP is presented. The basis of the subdivision of receptors for purines into P1-purinoceptors for adenosine and P2-purinoceptors for ATP and ADP are considered, as well as the recent proposal for subdivision of the ATP receptors into P2X-, P2Y-, P2Z-, and P2T- purinoceptor subtypes. These purinoceptor subtypes are discussed with respect to their transduction mechanisms, their distribution, and their physiological roles, including their roles in cotransmission and neuromodulation.

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Adenosine TriphosphateAnimalsModels, BiologicalNeurotransmitter AgentsReceptors, PurinergicJournal ArticleReview

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G Burnstock. 1990. Overview. Purinergic mechanisms.. https://doi.org/10.1111/j.1749-6632.1990.tb37657.x

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