Osteosarcoma in young children.

H Kozakewich; A R Perez-Atayde; A M Goorin; R H Wilkinson; M C Gebhardt; G F Vawter

doi:10.1002/1097-0142(19910201)67:3<638::aid-cncr2820670319>3.0.co;2-t

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PubMed · 1985758

Osteosarcoma in young children.

H Kozakewich·A R Perez-Atayde·A M Goorin·R H Wilkinson·M C Gebhardt·G F Vawter

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Abstract

The clinicopathologic features of osteosarcoma in 12 children younger than 16 years of age treated at The Children's Hospital and Dana-Farber Cancer Institute, Boston, during a 70-year time period are presented. Only one of six children treated before 1972 is a long-term survivor. Four of six children (67%) treated after 1972 are disease-free with an average follow-up of 8.8 years. The year 1972 marked the onset of use of effective chemotherapy in osteosarcoma, namely, high-dose methotrexate and leucovorin rescue. It would appear that the pathologic features and behavior of osteosarcoma in young children is similar to that of osteosarcoma in older children and adolescents. A combination of complete (wide) surgical resection or amputation and aggressive chemotherapy offers the best chance of long-term survival.

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H Kozakewich, A R Perez-Atayde, A M Goorin, R H Wilkinson, M C Gebhardt, G F Vawter. 1991-02-01. Osteosarcoma in young children.. https://doi.org/10.1002/1097-0142(19910201)67%3A3%3C638%3A%3Aaid-cncr2820670319%3E3.0.co%3B2-t

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