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PubMed · 1989917

Does intraperitoneal CA-125 reflect disease status?

R E Buller·A Manetta·J D Bloss·P J DiSaia·M L Berman
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Abstract

The relationship of serum CA-125 to intraperitoneal (IP) CA-125 was studied in 45 patients with a variety of gynecologic diseases including ovarian carcinoma. In 43 of 45 patients the IP level exceeded the serum level of CA-125. Paracentesis may dramatically alter both levels, thus mimicking surgical debulking. All IP levels of CA-125 measured at second-look coeliotomy for the ovarian cancer patients were within the normal range of IP CA-125 measured at surgery for benign disease. Therefore, intraperitoneal CA-125 is less sensitive than serum CA-125 in predicting intraperitoneal disease status. Likewise it cannot be used to predict the subgroup of ovarian cancer patients with negative second-look coeliotomy who are destined to develop a recurrence of disease.

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Antigens, Tumor-Associated, CarbohydrateAscitic FluidFemaleHumansOvarian NeoplasmsPeritoneal DiseasesRadioimmunoassayJournal Article

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R E Buller, A Manetta, J D Bloss, P J DiSaia, M L Berman. 1991. Does intraperitoneal CA-125 reflect disease status?. https://doi.org/10.1016/0090-8258(91)90087-l

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