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B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits.

C Murre·A Voronova·D Baltimore
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Abstract

Recent studies have identified a family of DNA-binding proteins that share a common DNA-binding and dimerization domain with the potential to form a helix-loop-helix (HLH) structure. Various HLH proteins can form heterodimers that bind to a common DNA sequence, termed the E2-box. We demonstrate here that E2-box-binding B-cell- and myocyte-specific nuclear factors contain subunits which are identical or closely related to ubiquitously expressed (E12/E47) HLH proteins. These biochemical function for E12/E47-like molecules in mammalian differentiation, similar to the genetically defined function of daughterless in Drosophila development.

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AnimalsB-LymphocytesBase SequenceBinding SitesCell LineCell NucleusDNADNA-Binding ProteinsEnhancer Elements, GeneticHeLa CellsHumansMacromolecular SubstancesMolecular Sequence DataMusclesProtein BiosynthesisProtein ConformationTranscription, GeneticJournal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.

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C Murre, A Voronova, D Baltimore. 1991. B-cell- and myocyte-specific E2-box-binding factors contain E12/E47-like subunits.. https://doi.org/10.1128/mcb.11.2.1156-1160.1991

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