How proteins enter the nucleus.

P A Silver

doi:10.1016/0092-8674(91)90233-o

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How proteins enter the nucleus.

P A Silver

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Abstract

Nuclear protein import is a selective process. Proteins destined for the nucleus contain NLSs. These short stretches of amino acids interact with proteins located in the cytoplasm, on the nuclear envelope, and/or at the nuclear pore complex. Following binding at the pore complex, proteins are translocated through the pore into the nucleus in a manner requiring ATP. The biochemical dissection of the nuclear pore complex has begun. Alteration of protein import into the nucleus is emerging as a new and complex form of regulation. However, we are left with the following problems: How do proteins move through the cytoplasm to reach the nuclear pore? How does the nuclear pore complex open and close in a selective manner? How is ATP utilized during import? And finally, how is bi-directional traffic of both proteins and RNA through the pore regulated?

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Adenosine Triphosphate Amino Acid Sequence Animals Biological Transport, Active Cell Compartmentation Cell Cycle Cell Nucleus DNA Mutational Analysis Molecular Sequence Data Nuclear Envelope Nuclear Proteins Structure-Activity Relationship Journal Article Research Support, Non-U.S. Gov't Review

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P A Silver. 1991-02-08. How proteins enter the nucleus.. https://doi.org/10.1016/0092-8674(91)90233-o

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