Thymus colonization in the developing mouse embryo.

R Palacios; J Samaridis

doi:10.1002/eji.1830210117

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Thymus colonization in the developing mouse embryo.

R Palacios·J Samaridis

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Abstract

We have directly followed the formation of and the thymus colonization by pro-T lymphocytes in the developing C57BL/6 mouse embryo by using the monoclonal antibody JORO 37-5 specific for pro-T lymphocytes, immunofluorescence staining and flow fluorocytometry or microscopy analysis. The results show that JORO 37-5+ cells begin to appear in the liver at day 9 of gestation. These JORO 37-5+ cells migrate to and colonize the thymus 1 day later, where they expand vigorously during the next 4-5 days and, subsequently, switch off expression of JORO 37-5 as they further differentiate into mature thymocytes.

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Animals Antibodies, Monoclonal Antigens, Differentiation, T-Lymphocyte Gestational Age Liver Mice Mice, Inbred C57BL T-Lymphocytes Thymus Gland Journal Article Research Support, Non-U.S. Gov't

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R Palacios, J Samaridis. 1991. Thymus colonization in the developing mouse embryo.. https://doi.org/10.1002/eji.1830210117

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