Minimal Rev-response element for type 1 human immunodeficiency virus.

X J Huang; T J Hope; B L Bond; D McDonald; K Grahl; T G Parslow

doi:10.1128/jvi.65.4.2131-2134.1991

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Minimal Rev-response element for type 1 human immunodeficiency virus.

X J Huang·T J Hope·B L Bond·D McDonald·K Grahl·T G Parslow

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Abstract

Rev protein regulates nuclear export of viral mRNAs that contain a 240-base RNA sequence termed the Rev-response element (RRE). We demonstrate that an 88-base truncated RRE encompassing a known Rev binding site can mediate Rev responsiveness in vivo. Two tandem copies of this mutant function as efficiently as the full-length RRE.

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Base Sequence Binding Sites Genes, env HIV-1 Molecular Sequence Data Mutation Nucleic Acid Conformation RNA, Messenger Repetitive Sequences, Nucleic Acid Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

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X J Huang, T J Hope, B L Bond, D McDonald, K Grahl, T G Parslow. 1991. Minimal Rev-response element for type 1 human immunodeficiency virus.. https://doi.org/10.1128/jvi.65.4.2131-2134.1991

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