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PubMed · 2006539

Receptor classification using antagonists without determining pA2 values.

W Kromer
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Abstract

Albeit time-consuming, the most rigorous method of classification of receptor subtypes is the determination of pA2 values. However, this methodology requires the knowledge of absolute concentrations of both agonists and antagonists--something that may not necessarily be calculable under certain experimental conditions. Wolfgang Kromer offers a different method for classification using antagonists which is not dependent on absolute affinities, and which has the additional advantage of speed.

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AlkaloidsBinding, CompetitiveFuransMuscarinic AntagonistsNaphthalenesPiperidinesPirenzepineReceptors, MuscarinicJournal ArticleReview

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BibTeXRIS

W Kromer. 1991. Receptor classification using antagonists without determining pA2 values.. https://doi.org/10.1016/0165-6147(91)90482-8

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