Prothymocyte seeding in the thymus.

H C O'Neill

doi:10.1016/0165-2478(91)90234-2

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PubMed · 2019416

Prothymocyte seeding in the thymus.

H C O'Neill

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Abstract

A major gap in our understanding of T lymphocyte development is the process of stem cell differentiation into T lymphocyte precursors. An important question is whether bone marrow-derived stem cells become committed to T lymphoid lineage within the bone marrow, or whether this occurs once cells have entered the microenvironment of the thymus. Attempts to identify a haemapoietic precursor of thymocytes in mice, a "prothymocyte", have involved cell transfer experiments involving isolated and selected populations of bone marrow stem cells, as well as transformed or continuous cell lines representing early stage in mouse T cell development. Current information on the properties of stem cells which can seed the thymus is reviewed in this paper, and the possibility that progenitor T cells may be identified by their expression of receptor(s) which localise them into the thymus is considered.

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Animals Cell Differentiation Cell Line Cell Movement Stem Cells T-Lymphocytes Thymus Gland Journal Article Review

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H C O'Neill. 1991. Prothymocyte seeding in the thymus.. https://doi.org/10.1016/0165-2478(91)90234-2

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