Site-specific gene therapy for cardiovascular disease.

Ilia Fishbein; Michael Chorny; Robert J Levy

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PubMed · 20205054

Site-specific gene therapy for cardiovascular disease.

Ilia Fishbein·Michael Chorny·Robert J Levy

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Abstract

Gene therapy holds considerable promise for the treatment of cardiovascular disease and may provide novel therapeutic solutions for both genetic disorders and acquired pathophysiologies such as arteriosclerosis, heart failure and arrhythmias. Recombinant DNA technology and the sequencing of the human genome have made a plethora of candidate therapeutic genes available for cardiovascular diseases. However, progress in the field of gene therapy for cardiovascular disease has been modest; one of the key reasons for this limited progress is the lack of gene delivery systems for localizing gene therapy to specific sites to optimize transgene expression and efficacy. This review summarizes progress made toward the site-specific delivery of cardiovascular gene therapy and highlights selected promising novel approaches.

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Animals Cardiovascular Diseases Gene Transfer Techniques Genetic Therapy Genetic Vectors Humans Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

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Ilia Fishbein, Michael Chorny, Robert J Levy. 2010. Site-specific gene therapy for cardiovascular disease.. https://pubmed.ncbi.nlm.nih.gov/20205054/

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