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Novel avermectins produced by mutational biosynthesis.

C J Dutton·S P Gibson·A C Goudie·K S Holdom·M S Pacey·J C Ruddock·J D Bu'Lock·M K Richards
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Abstract

Avermectins with a wide range of novel C-25 substituents have been prepared by feeding carboxylic acids or their biosynthetic precursors to a Streptomyces avermitilis mutant strain ATCC 53568. This organism lacks the ability to form isobutyric and S-2-methylbutyric acids from their 2-oxo acid precursors and thus is unable to produce natural avermectins unless supplied with these acids. The novel avermectins produced by mutational biosynthesis possess broad-spectrum antiparasitic activity.

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AnimalsAnthelminticsCaenorhabditisCarboxylic AcidsChromatography, High Pressure LiquidDipteraFermentationIvermectinMolecular StructureMutationStreptomycesJournal Article

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BibTeXRIS

C J Dutton, S P Gibson, A C Goudie, K S Holdom, M S Pacey, J C Ruddock, J D Bu'Lock, M K Richards. 1991. Novel avermectins produced by mutational biosynthesis.. https://doi.org/10.7164/antibiotics.44.357

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